A new study led by Pierre Close’s team (GIGA, Laboratory of Cancer Signaling, and WELRI Investigator) reveals how subtly disrupting the way tumors produce their proteins can trigger a potent antitumor immune response.

Published in Cell, an international study involving researchers from the GIGA-Cancer Institute uncovers a new mechanism of immune evasion in melanoma, paving the way for novel strategies to enhance immunotherapy.

The Fondation Contre le Cancer is supporting the projects of Pierre Foidart, Céline Grégoire and Alexandra Veloso for a period of 4 years.

Pierre Close (Cancer Signaling Laboratory - GIGA Stem Cells) has been selected for his project "Demystifying what makes melanoma so good at resisting treatments" and is receiving £155,000 in funding.

In an article published in Nature Communications, Francesca Rapino & Pierre Close, from the Laboratory of Cancer Signaling (GIGA), discover how the modification of transfer RNAs impacts the dynamics of protein expression.

This grant will allow him to continue his research in order to study the role(s) of mTORC2 in mRNA translation and cellular metabolism, in the context of lung cancer development.