Selected publications of the lab

Wobble tRNA modification and hydrophilic amino acid patterns dictate protein fate

Wobble tRNA modification and hydrophilic amino acid patterns dictate protein fate.

Nat Communication, 2021, DOI: 10.1038/s41467-021-22254-5.

Wobble uridine tRNA modification: a new vulnerability of refractory melanoma.
Rapino F & Close P.
Molecular & Cellular Oncology,  2018, DOI: 10.1080/23723556.2018.1513725

Codon-specific translation reprogramming promotes resistance to targeted therapy.
Rapino F, Delaunay S, Rambow F, Zhou Z, Tharun L, De Tullio P, Sin O, Shostak K, Schmitz S, Piepers J, Ghesquière B, Karim L, Charloteaux B, Jamart D, Florin A, Lambert C, Rorive A, Jerusalem G, Leucci E, Dewaele M, Vooijs M, Leidel SA, Georges M, Voz M, Peers B, Büttner R, Marine JC, Chariot A, Close P.
Nature. 2018 Jun 20. doi: 10.1038/s41586-018-0243-7.

Dynamic regulation of tRNA modifications in cancer.
Pierre Close, Debojit Bose, Alain Chariot,  and Sebastian Leidel.
Cancer and Noncoding RNAs, Elsevier 2018, 163-177

tRNA modification: Is cancer having a wobble?
Francesca Rapino, Sylvain Delaunay, Zhaoli Zhou, Alain Chariot and Pierre Close.
Trends in Cancer 2017 April; 3(4):249-252. 

Elp3 links tRNA modification to IRES-dependent translation of LEF1 to sustain metastasis in breast cancer.
Delaunay S, Rapino F, Tharun L, Zhou Z, Heukamp L, Termathe M, Shostak K, Klevernic I, Florin A, Desmecht H, Desmet CJ, Nguyen L, Leidel SA, Willis AE, Büttner R, Chariot A, Close P.
J Exp Med. 2016 Oct 17;213(11):2503-2523.

Elp3 drives Wnt-dependent tumor initiation and regeneration in the intestine.
Ladang A*, Rapino F*, Heukamp LC, Tharun L, Shostak K, Hermand D, Delaunay S, Klevernic I, Jiang Z, Jacques N, Jamart D, Migeot V, Florin A, Göktuna S, Malgrange B, Sansom OJ, Nguyen L, Büttner R, Close P§, Chariot A§ (*co-first authors; §co-last authors).
J Exp Med. 2015 Nov 2. pii: jem.20142288.

DBIRD complex integrates alternative mRNA splicing with RNA polymerase II transcript elongation.
Close P, East P, Dirac-Svejstrup AB, Hartmann H, Heron M, Maslen S, Chariot A, Söding J, Skehel M, Svejstrup JQ.
Nature. 2012 Mar 25;484(7394):386-9. doi: 10.1038/nature10925.